15-Deoxy-Δ-12,14-prostaglandin J2-d4 is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. It is a selective PPARγ (EC50 of 2 μM) and a covalent PPARδ agonist, promoting efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.